Featured Publications

 

Radiolabelling Method Development

 

Electrochemical Radiofluorination of Small Molecules: New Advance

Daniel Hernández-Valdés and Saman Sadeghi. "Electrochemical Radiofluorination of Small Molecules: New Advance". The Chemical Record. 2021, 21, 1–15

Imidazole fused phenanthroline (PIP) ligands for the preparation of multimodal Re(i) and 99mTc(i) probes

Slikboer et al., “Imidazole Fused Phenanthroline (PIP) Ligands for the Preparation of Multimodal Re(I) and 99mTc(I) Probes.” Dalton Transactions. 2020.

Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor

A Lebedev, J Jiao, J Lee, F Yang, N Allison, H Herschman, S Sadeghi ( 2017) Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor PloS one 12 (5), e0176606 PMCID:  PMC5413030

An automated synthesizer for electrochemical 18F-fluorination of organic compounds

Waldmann CM, Lebedev A, Allison N, Sadeghi S. (2017) An automated synthesizer for electrochemical 18F-fluorination of organic compounds. Appl Radiat Isot.

 

Diagnostic Radiopharmceuticals

 

Synthesis and Preclinical Evaluation of [ 18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model

Justin Bailey, Melinda Wuest, Michael Wagner, Atul Bhardwaj, Carmen Wängler, Bjoern Wängler, John Valliant, Ralf Schirrmacher, Frank Wuest. "Synthesis and Preclinical Evaluation of [ 18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model". Journal of Medicinal Chemistry. 2021, 64. 10.1021/acs.jmedchem.1c00812.

Tc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting

Afaf Genady, Darryl Fong, Samantha Slikboer, Mohamed El-Zaria, Mohamed, Rowan Swann, Nancy Janzen, Amber Faraday, Stuart Mcnelles, Mojgan Rezvani, Saman Sadeghi, Alex Adronov, John Valliant. "Tc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting". Nano Materials Science. 2020, 3. 10.1021/acsanm.0c02339

99mTc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting

Afaf R. Genady, Darryl Fong​, Samantha R. Slikboer, Mohamed E. El-Zaria, Rowan Swann, Nancy Janzen, Amber Faraday, Stuart A. McNelles, Mojgan Rezvani, Saman Sadeghi, Alex Adronov, and John F. Valliant

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Momcilovic M, Jones A, Bailey S, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB (2019) In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature  (575), 380–384 PMID: 31666695

In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures

Johann Le Floc’h , Aimen Zlitni, Holly A. Bilton, Melissa Yin, Arash Farhadi, Nancy R. Janzen, Mikhail G. Shapiro, John F. Valliant, F. Stuart Foster. Mol. Imaging Biol. 2018; 20:230-239. DOI: 10.1007/s11307-017-1122-6.

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. (2017) Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep.18(3):601-610. PMID: 28099841; PMCID: PMC5260616.

Preparation of an 18F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species

Salma Al-Karmi, Silvia A. Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta, John F Valliant,   From Chemistry - A European Journal 2017, 23(2), 254-258.

67Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes

Joseph A. Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F. Valliant, Paul J Berti.   From Nuclear Medicine and Biology 2017, 52, 32-41.  | Language: English, Database: CAPLUS

Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: The Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile

Vincent Bouvet, Melinda Wuest, Justin J. Bailey, Cody Bergman, Nancy Janzen, John F. Valliant, Frank Wuest.   From Molecular Imaging and Biology 2017, 19(6), 923-932

 

Bio-orthogonal Chemistry 

 

Pretargeted PET of Osteodestructive Lesions in Dogs

Charles Matiz, Samantha Delaney, Brendon Cook, Afaf Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John Valliant, Saman Sadeghi, Jason Lewis, Heather Hennkens, Jeffrey Bryan, & Brian Zeglis. "Pretargeted PET of Osteodestructive Lesions in Dogs". Molecular Pharmaceutics 2022. 10.1021/acs.molpharmaceut.2c00220.

A Bioorthogonal Methylene Blue Derived Probe for Targeted Photoacoustic Imaging

Afaf Genady, Samantha Slikboer, Rowan Swann, Kevin Wyszatko, Nancy Janzen, Luis Silva, Mohamed El-Zaria, Saman Sadeghi, John Valliant. "A Bioorthogonal Methylene Blue Derived Probe for Targeted Photoacoustic Imaging". European Journal of Medicinal Chemistry Reports. 2021, 4. 100021. 10.1016/j.ejmcr.2021.100021.

A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules

Stephanie Rathmann, Afaf Genady, Nancy Janzen, Varun Anipindi, Shannon Czorny, Anthony Rullo, Saman Sadeghi, John Valliant. A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules. Molecular Pharmaceutics. 2021, 18. 10.1021/acs.molpharmaceut.1c00187

Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents

Slikboer et al. Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents,
Mol. Pharmaceutics 2020, 17, 3369−3377

Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels-Alder chemistry

Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, Robert G. Ungard, Tanya Miladinovic, Gurmit Singh, John F. Valliant.  From Dalton Transactions 2017, 46(42), 14691-14699.

 

Therapeutic Radiopharmaceuticals

 

Combined internal radionuclide therapy and immunotherapy for treatment of triple negative breast cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader Sayes, Karen Mossman, John Valliant. "Combined internal radionuclide therapy and immunotherapy for treatment of triple negative breast cancer". International Journal of Molecular Sciences. 2021, 22. 4843. 10.3390/ijms22094843