Featured Publications
Radiolabelling Method Development
Electrochemical Radiofluorination of Small Molecules: New Advance
Daniel Hernández-Valdés and Saman Sadeghi. "Electrochemical Radiofluorination of Small Molecules: New Advance". The Chemical Record. 2021, 21, 1–15
Imidazole fused phenanthroline (PIP) ligands for the preparation of multimodal Re(i) and 99mTc(i) probes
Slikboer et al., “Imidazole Fused Phenanthroline (PIP) Ligands for the Preparation of Multimodal Re(I) and 99mTc(I) Probes.” Dalton Transactions. 2020.
Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor
A Lebedev, J Jiao, J Lee, F Yang, N Allison, H Herschman, S Sadeghi ( 2017) Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor PloS one 12 (5), e0176606 PMCID: PMC5413030
An automated synthesizer for electrochemical 18F-fluorination of organic compounds
Waldmann CM, Lebedev A, Allison N, Sadeghi S. (2017) An automated synthesizer for electrochemical 18F-fluorination of organic compounds. Appl Radiat Isot.
Diagnostic Radiopharmceuticals
Synthesis and Preclinical Evaluation of [ 18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model
Justin Bailey, Melinda Wuest, Michael Wagner, Atul Bhardwaj, Carmen Wängler, Bjoern Wängler, John Valliant, Ralf Schirrmacher, Frank Wuest. "Synthesis and Preclinical Evaluation of [ 18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model". Journal of Medicinal Chemistry. 2021, 64. 10.1021/acs.jmedchem.1c00812.
Tc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting
Afaf Genady, Darryl Fong, Samantha Slikboer, Mohamed El-Zaria, Mohamed, Rowan Swann, Nancy Janzen, Amber Faraday, Stuart Mcnelles, Mojgan Rezvani, Saman Sadeghi, Alex Adronov, John Valliant. "Tc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting". Nano Materials Science. 2020, 3. 10.1021/acsanm.0c02339
99mTc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting
Afaf R. Genady, Darryl Fong, Samantha R. Slikboer, Mohamed E. El-Zaria, Rowan Swann, Nancy Janzen, Amber Faraday, Stuart A. McNelles, Mojgan Rezvani, Saman Sadeghi, Alex Adronov, and John F. Valliant
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
Momcilovic M, Jones A, Bailey S, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB (2019) In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature (575), 380–384 PMID: 31666695
In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures
Johann Le Floc’h , Aimen Zlitni, Holly A. Bilton, Melissa Yin, Arash Farhadi, Nancy R. Janzen, Mikhail G. Shapiro, John F. Valliant, F. Stuart Foster. Mol. Imaging Biol. 2018; 20:230-239. DOI: 10.1007/s11307-017-1122-6.
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. (2017) Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep.18(3):601-610. PMID: 28099841; PMCID: PMC5260616.
Preparation of an 18F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species
Salma Al-Karmi, Silvia A. Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta, John F Valliant, From Chemistry - A European Journal 2017, 23(2), 254-258.
67Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes
Joseph A. Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F. Valliant, Paul J Berti. From Nuclear Medicine and Biology 2017, 52, 32-41. | Language: English, Database: CAPLUS
Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: The Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile
Vincent Bouvet, Melinda Wuest, Justin J. Bailey, Cody Bergman, Nancy Janzen, John F. Valliant, Frank Wuest. From Molecular Imaging and Biology 2017, 19(6), 923-932
Bio-orthogonal Chemistry
Pretargeted PET of Osteodestructive Lesions in Dogs
Charles Matiz, Samantha Delaney, Brendon Cook, Afaf Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John Valliant, Saman Sadeghi, Jason Lewis, Heather Hennkens, Jeffrey Bryan, & Brian Zeglis. "Pretargeted PET of Osteodestructive Lesions in Dogs". Molecular Pharmaceutics 2022. 10.1021/acs.molpharmaceut.2c00220.
A Bioorthogonal Methylene Blue Derived Probe for Targeted Photoacoustic Imaging
Afaf Genady, Samantha Slikboer, Rowan Swann, Kevin Wyszatko, Nancy Janzen, Luis Silva, Mohamed El-Zaria, Saman Sadeghi, John Valliant. "A Bioorthogonal Methylene Blue Derived Probe for Targeted Photoacoustic Imaging". European Journal of Medicinal Chemistry Reports. 2021, 4. 100021. 10.1016/j.ejmcr.2021.100021.
A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules
Stephanie Rathmann, Afaf Genady, Nancy Janzen, Varun Anipindi, Shannon Czorny, Anthony Rullo, Saman Sadeghi, John Valliant. A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules. Molecular Pharmaceutics. 2021, 18. 10.1021/acs.molpharmaceut.1c00187
Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents
Slikboer et al. Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents,
Mol. Pharmaceutics 2020, 17, 3369−3377
Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels-Alder chemistry
Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, Robert G. Ungard, Tanya Miladinovic, Gurmit Singh, John F. Valliant. From Dalton Transactions 2017, 46(42), 14691-14699.
Therapeutic Radiopharmaceuticals
Combined internal radionuclide therapy and immunotherapy for treatment of triple negative breast cancer
Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader Sayes, Karen Mossman, John Valliant. "Combined internal radionuclide therapy and immunotherapy for treatment of triple negative breast cancer". International Journal of Molecular Sciences. 2021, 22. 4843. 10.3390/ijms22094843